Blood-Brain-Barrier

Generation of 3D co-culture models to mimic the barrier integrity of epithelial and endothelial cells

Brain is such a complicated tissue with many different cell types implicated in its normal- and patho-physiology that it imposes a high hurdle for generating in vitro models close to its natural tissue microenvironment. Qureator’s 3D co-culture organ-on-a chip platform allows researchers not only to investigate the intricate biological responses from the interactions between different cell types in the brain but also to reconstitute conditions unique to it such as the blood-brain-barrier (BBB).

Migration of astrocytesClick to Expand
Migration of astrocytes to the vascular network
Vascular network-astrocytes interfaceClick to Expand
Vascular network-astrocytes interface
blood-brain-barrierClick to Expand
Migration of astrocytes
Vascular network-astrocytes interface
blood-brain-barrier

Publications

Blood-brain-barrier (BBB) model

3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro
A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes
Modeling neural circuit, blood–brain barrier, and myelination on a microfluidic 96 well plate

Developing Robust
Physiologically Relevant
Disease Models
for High-throughput
Drug Discovery

Contact Us
Developing Robust content media