Vascular biology is one of the research areas where Qureator’s organ-on-a-chip platform has been widely used by numerous investigators in studying a variety of diseases, as indicated in the following publications. The platform has been optimized over the years to form robust vasculatures in a highly reproducible manner and its compartmented multi-channel structure is suited for culturing different cell types simultaneously, thus allowing their interactions with vasculatures. The chip can be used not only for performing a variety of endothelial cell assays with simple readouts but also for mimicking more complex disease states such as age-related macular degeneration (AMD) where both endothelial and non-endothelial cells contribute to the manifestation of pathology.
Interstitial flow regulates angiogenic response and phenotype of endothelial cells in a 3D culture model
Vascular toxicity assay
Vascular permeability assay
Chemotaxis assay for leukocytes
Vascular Mimetics Based on Microfluidics for Imaging the Leukocyte-Endothelial Inflammatory Response
Drug delivery test
Liposomal co-delivery-based quantitative evaluation of chemosensitivity enhancement in breast cancer stem cells by knockdown of GRP78/CLU